I started 4.5 mg of Low Dose Naltrexone (LDN) on November 1, a little over a week ago.
I’m also continuing on Humira, one shot every other week (today is a Humira day). I’ve read that since Humira suppresses the immune system and LDN stimulates it it’s not good to take them together but my doctor thought it would be ok. Also she doesn’t want me stopping Humira since it seems to be helping a little. I still have significant symptoms but I think some things have improved since I started it six weeks ago.
From what I’ve read LDN increases the release of endorphins in the 24 hours after you take it and these help rebalance and heal the immune system. Many people with illnesses influenced by the immune system not working correctly have found it helpful.
I was relieved after taking LDN once not to have any of the side effects listed (the most frequent one is sleep disturbances like insomnia or scary vivid dreams). I have been feeling a bit more alert and happy during the day since I’ve been taking it, which of course is welcome. This could be due to the endorphins (or a placebo effect, but I don’t think it’s just that). Many days I’m still tired enough to need naps but I’m able to do more during the day than before I was taking it.
I’ve read that LDN can make symptoms worse before they get better. This week I wouldn’t say they’ve been significantly worse or better. They fluctuate somewhat for reasons I don’t particularly understand.
Since I’m not having problems taking LDN and I seem to feel a bit better generally because of it I’m going to continue taking it and see what happens.